High relative fat-free mass is important for maintaining serum albumin levels in patients with compensated liver cirrhosis世界胃肠病学杂志：英文版论文

High relative fat-free mass is important for maintaining serum albumin levels in patients with compensated liver cirrhosis世界胃肠病学杂志：英文版论文

【题名】：High relative fat-free mass is important for maintaining serum albumin levels in patients with compensated liver cirrhosis世界胃肠病学杂志：英文版论文(High relative fat-free mass is important for maintaining serum albumin levels in patients with compensated liver cirrhosisShiJieWeiChangBingXueZaZhi：YingWenBanLunWen)
【关键词】：免疫白蛋白代偿性肝硬化营养学肥胖肌肉
【keywords】：MianYiBaiDanBai DaiChangXingGanYingHua YingYangXue FeiPang JiRou
【作者】：KazuhiroKotoh,MakotoNakamuta,MarieFukushima,ChitoseMatsuzaki,MunechikaEnjoji,HironoriSakai,HajimeNawata,      【来源】：知识词典
【期刊名称】：世界胃肠病学杂志：英文版(ShiJieWeiChangBingXueZaZhi：YingWenBan)
【国际标准刊号】：1007-9327        【国内统一刊号】：14-1219
【作者单位】：[1]DepartmentofMedicineandBioregulatoryScience,GraduateSchoolofMedicalSciences,KyushuUniversity,Fukuoka812-8582,Japan [2]DepartmentofGastroenterology,NationalHospitalOrganizationKyushuMedicalCenter,Fukuoka812-8582,Japan([1]DepartmentofMedicineandBioregulatoryScience,GraduateSchoolofMedicalSciences,KyushuUniversity,Fukuoka812-8582,Japan [2]DepartmentofGastroenterology,NationalHospitalOrganizationKyushuMedicalCenter,Fukuoka812-8582,Japan)
【分类号】：R575.2      【页码】：-1356-1360      【出版年】：2005.9
        AIM: In patients with liver cirrhosis, hypoalbuminemia causes edema and ascites, and a reduction in the quality of life, Since musculature is catabolized to supply amino acids for albumin synthesis in malnutritional cirrhotic patients, muscular volume is hypothesized to play an important role in albumin production, Therefore, we investigated the correlation between serum albumin levels and the fat-free mass (FFM) in cirrhotic patients, METHODS: Fifty-seven patients (26 males and 31 females) with compensated liver cirrhosis were evaluated. Patients with edema or ascites were excluded from the study. Healthy volunteers (n = 104, 48 males and 56 females) were also evaluated as controls. FFM was measured using 5-500 kHz multifrequency bioelectric impedance analysis. To minimize the difference in FFM distribution between males and females, we introduced a new marker, relative FFM (rFFM), which represents the ratio of FFM in a patient relative to that in a volunteer of the same height. Following FFM measurement, the serum albumin levels of patients were assayed monthly. RESULTS: In patients with active cirrhosis (alanine aminotransaminase [ALT] >50 U/L), both albumin (the difference between maximum and minimum levels) and the standard deviation of albumin levels (SD-albumin) during the observation period showed a significant correlation with rFFM. Multiple linear regression analysis using variables such as rFFM, platelet number, and serum cholesterol levels, choline esterase, albumin, bilirubin, and ALT revealed that rFFM and ALT were significant and independent factors that influenced albumin or SD-albumin in cirrhotic patients. CONCLUSION: Our results indicate that cirrhotic patients with high rFFM showed less of a decrease in albumin levels, and that the muscle volume is one of the most important factors for maintaining serum albumins level in active cirrhosis. Exercise and protein-rich nutrition at the early stage of liver cirrhosis may be advisable for maintaining or increasing muscular volume.

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