Integrins mediating bone signal transduction重庆大学学报：英文版论文
【题名】：Integrins mediating bone signal transduction重庆大学学报：英文版论文(Integrins mediating bone signal transductionZhongQingDaXueXueBao：YingWenBanLunWen) 【关键词】：额外细胞矩阵 信号转导 整合蛋白中介 骨骼吸收 骨骼构成 【keywords】：EWaiXiBaoJuZhen XinHaoZhuanDao ZhengHeDanBaiZhongJie GuZuoXiShou GuZuoGouCheng 【作者】：HEChuanglong,WANGYuanliang,YANGLihua,ZHANGJun,      【来源】： 知识词典 【期刊名称】：重庆大学学报：英文版(ZhongQingDaXueXueBao：YingWenBan) 【国际标准刊号】：1671-8224        【国内统一刊号】：50-1142/N 【作者单位】：[1]KeyLaboratoryforBiomechanics＆TissueEngineeringUndertheMinistryofEducation,ChongqingUniversity,Chongqing400030,P.R.China [2]BioengineeringCollege,ChongqingUniversity,Chongqing400030,P.R.China([1]KeyLaboratoryforBiomechanics＆TissueEngineeringUndertheMinistryofEducation,ChongqingUniversity,Chongqing400030,P.R.China [2]BioengineeringCollege,ChongqingUniversity,Chongqing400030,P.R.China) 【分类号】：R322.71 Q51      【页码】：-55-60      【出版年】：2004.1 【下载地址】：下载pdf全文         Integrin-mediated adhesions play critical roles in diverse cell functions. Integrins offers a platform on which mechanicalstimuli, cytoskeletal organization, biochemical signals can concentrate. Mechanical stimuli transmitted by integrins influence thecytoskeleton, in turn, the cytoskeleton influences cell adhesion via integrins, then cell adhesion results in a series of signaltransduction cascades. In skeleton, integrins also have a key role for bone resoption by osteoclasts and reformation byosteoblasts. In present review, the proteins involved in integrin signal transduction and integrin signal transduction pathways werediscussed, mainly on the basic mechanisms of integrin signaling and the roles of integrins in bone signal transduction, which maygive insight into new therapeutic agents to all kinds of skeletal diseases and new strategies for bone tissue engineering.
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