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世界胃肠病学杂志：英文版 |
| Hepatocellular apoptosis after hepatectomy in obstructive jaundice in rats世界胃肠病学杂志：英文版论文 |
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【题名】：Hepatocellular apoptosis after hepatectomy in obstructive jaundice in rats世界胃肠病学杂志：英文版论文(Hepatocellular apoptosis after hepatectomy in obstructive jaundice in ratsShiJieWeiChangBingXueZaZhi：YingWenBanLunWen)
【关键词】：梗塞性黄疸 肝切除术 动物实验 肝细胞 细胞凋亡
【keywords】：GengSaiXingHuangZuo GanQieChuShu DongWuShiYan GanXiBao XiBaoDiaoWang
【作者】：De-ShengWang Ke-FengDou Kai-ZongLi Zhi-QingGao Zhen-ShunSong Zheng-CaiLiu 【来源】： 知识词典
【期刊名称】：世界胃肠病学杂志：英文版(ShiJieWeiChangBingXueZaZhi：YingWenBan)
【国际标准刊号】：1007-9327 【国内统一刊号】：14-1219
【作者单位】：DepartmentofHepatobiliarySurgery,XijingHospital,theFourthMilitaryMedicalUniversity,Xi‘an710032,ShannxiProvince,China(DepartmentofHepatobiliarySurgery,XijingHospital,theFourthMilitaryMedicalUniversity,Xi‘an710032,ShannxiProvince,China)
【分类号】：R657.3 【页码】：-2737-2741 【出版年】：2003.12
【下载地址】：下载pdf全文
AIM: To investigate the hepatocellular apoptosis after hepatectomy in obstructive jaundice and biliary decompression rats.METHODS: After bile duct ligation for 7 days, rats were randomly divided into OB group in which the rats underwent 70% hepatectomy, OB-CD group in which the rats underwent hepatectomy accompanied by choledochoduodenostomy, CD-Hx group in which the rats underwent choledochoduodenostomy and then received 70% hepatectomy on the fifth day after bilianl decompression. The control group (Hx group) only underwent hepatectomy.RESULTS: The level of total serum bilirubin and serum enzymes was significantly lower in CD-Hx group than in OB-CD and OB groups on day 1, 3 and 5 after hepatectomy. The apoptotic index was significantly lower in CD-Hx group than in OB-CD and OB groups on day 3 and 5. The oligonudeosomal DNA fragments and Caspase-3 activity were also lower in CD-Hx group than in OB-CD and OB groups 3 days after hepatectomy,without differences between CD-Hx and Hx groups.CONCLUSION: Hepatocellular apoptosis plays vital roles in jaundice rats, and biliary decompression is more effective in treatment of patients with severe jaundice before operation.
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