POTASSIUM CHANNELS ON CARDIOMYOCYTES OF SELENIUM IODINE DEFICIENCY RATS AND IODINE DEFICIENCY RATS中国医学科学杂志：英文版论文
【题名】：POTASSIUM CHANNELS ON CARDIOMYOCYTES OF SELENIUM IODINE DEFICIENCY RATS AND IODINE DEFICIENCY RATS中国医学科学杂志：英文版论文(POTASSIUM CHANNELS ON CARDIOMYOCYTES OF SELENIUM IODINE DEFICIENCY RATS AND IODINE DEFICIENCY RATSZhongGuoYiXueKeXueZaZhi：YingWenBanLunWen) 【关键词】：钾通道 硒缺乏 碘缺乏 动物模型 试验 【keywords】：JiaTongDao XiQueFa DianQueFa DongWuMoXing ShiYan 【作者】：鲍光宏 吴晖云 于德洁 刘东梅 王洪全      【来源】： 知识词典 【期刊名称】：中国医学科学杂志：英文版(ZhongGuoYiXueKeXueZaZhi：YingWenBan) 【国际标准刊号】：1001-9294        【国内统一刊号】：11-2752 【作者单位】：InstituteofBasicMedicalSciences,CAMS＆PUMC,Beijing100730(InstituteofBasicMedicalSciences,CAMS＆PUMC,Beijing100730) 【分类号】：R591.1 R-332      【页码】：-57-59      【出版年】：1997.1         Uging diet control method to feed the weaning male Wistar rats with selenium and iodine deficiency Keshan endemic area food for 8 weeks to set up animal model. Singal channel recording in cell attached model was used to measure cardiac cell membrane potassium channel conductances,which coincide with the cardiac cell membrane potassium channel conductances in normal Wistar rats. The potassium channel conductance on selenium and iodine deficiency rat cardiac cell membrane is showing current-voltage increasing lineally in the range of clamping volatge 0±30 mV with channel conductance of 43.4 pS. The channel current does not increase depending on the damping vottage that is showing the rectifying characteristic and the channel current amplitude can be augmented by added KIOa 5mmol/L in bath solution. A kind of inward rectiyfing potsssium channel activity was recorded,hut this channel activity disappeared after lasting 6～10 minutes only, Then an inward rectifying potassium channel with the conductance of 14, 2 pS was activated by KIOa 5 mmol/L introduced to bath solution. Both conductances are less than that of normal Wistar rats.
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