HDR-^192Ir intraluminal brachytherapy in treatment of malignant obstructive jaundice世界胃肠病学杂志：英文版论文
【题名】：HDR-^192Ir intraluminal brachytherapy in treatment of malignant obstructive jaundice世界胃肠病学杂志：英文版论文(HDR-^192Ir intraluminal brachytherapy in treatment of malignant obstructive jaundiceShiJieWeiChangBingXueZaZhi：YingWenBanLunWen) 【关键词】：HDR-^192Ir 管腔 短程治疗 恶性阻塞性黄疸 消化系统 【keywords】：HDR-^192Ir GuanQiang DuanChengZhiLiao EXingZuSaiXingHuangZuo XiaoHuaXiTong 【作者】：YiChen Xiao-LinWang Zhi-PingYan Jie-MinCheng Jian-HuaWang Gao-QuanGong ShengQian Jian-JunLuo Qing-XinUu      【来源】： 知识词典 【期刊名称】：世界胃肠病学杂志：英文版(ShiJieWeiChangBingXueZaZhi：YingWenBan) 【国际标准刊号】：1007-9327        【国内统一刊号】：14-1219/R 【作者单位】：DepartmentofRadiology,AffiliatedZhongshanHospital,MedicalCenterofFudanUniversity,Shanghai200032,China(DepartmentofRadiology,AffiliatedZhongshanHospital,MedicalCenterofFudanUniversity,Shanghai200032,China) 【分类号】：R575      【页码】：-3506-3510      【出版年】：2004.23 【下载地址】：下载pdf全文         AIM: To determine the feasibility and safety of intraluminal brachytherapy in treatment of malignant obstructive jaundice (MOJ) and to evaluate the clinical effect of intraluminal brachytherapy on stent patency and patient survival.METHODS: Thirty-four patients with MOJ were included in this study. Having biliary stent placed, all patients were classified into intraluminal brachytherapy group (group A,n=14) and control group (group B, n = 20) according to their own choice. Intraluminal brachytherapy regimen included: HDR-192Ir was used in the therapy, fractional doses of 4-7 Gy were given every 3-6 d for 3-4 times, and standard points were established at 0.5-1.0 cm. Some patients of both groups received transcatheter arterial chemoembolization (TACE) after stent placement.RESULTS: In group A, the success rate of intraluminal brachytherapy was 98.0%, RTOG grade 1 acute radiation morbidity occurred in 3 patients, RTOG/EORTC grade 1 late radiation morbidity occurred in 1 patient. Mean stent patency of group A (12.6 mo) was significantly longer than that of group B (8.3 mo) (P<0.05). There was no significant difference in the mean survival (9.4 mo vs6.0 mo) between the two groups.CONCLUSION: HDR-^192Ir intraluminal brachytherapy is a safe palliative therapy in treating MOJ, and it may prolong stent patency and has the potentiality of extending survival of patients with MOJ.
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