PLASMID VACCINE ENCODING HN GENE FROM NEWCASTLE DISEASE VIRUS HAS MARKED ANTITUMORAL EFFECT IN VITRO中国癌症研究：英文版论文
【题名】：PLASMID VACCINE ENCODING HN GENE FROM NEWCASTLE DISEASE VIRUS HAS MARKED ANTITUMORAL EFFECT IN VITRO中国癌症研究：英文版论文(PLASMID VACCINE ENCODING HN GENE FROM NEWCASTLE DISEASE VIRUS HAS MARKED ANTITUMORAL EFFECT IN VITROZhongGuoAiZhengYanJiu：YingWenBanLunWen) 【关键词】：HN基因 新城病病毒 疫苗 预防接种 p53 bcl-2 【keywords】：HNJiYin XinChengBingBingDu YiMiao YuFangJieZhong p53 bcl-2 【作者】：薛立娟 金宁一 龚伟 王宏伟 李萍      【来源】： 知识词典 【期刊名称】：中国癌症研究：英文版(ZhongGuoAiZhengYanJiu：YingWenBan) 【国际标准刊号】：1000-9604        【国内统一刊号】：11-2591 【作者单位】：QuartermasterUniversityofPLA,Changchun130062(QuartermasterUniversityofPLA,Changchun130062) 【分类号】：R392-33      【页码】：-161-166      【出版年】：2003.3         Objective: To explore the antitumor effects of hemaagglutinin-neuraminase gene (HN gene) from Newcastle disease virus. Methods: Plasmid vaccine of pIRHN was constructed and transfected into HeLa cells.The expression of HN was analyzed by Western blot analysis, and the mode of cell death was detected by fluorescence microscope, gel electrophoresis and TUNEL assay and the expression of p53 and bcl-2 was also analyzed in transfected Hela cells. The effect of pIRHN on sialic acid contents in the Hela cell was examined. Results: plRHN nucleic acid vaccines could be expressed in eukaryotic cell. pIRHN could induce apoptosis after HeLa cells were transfected. The effect of antitumor responses of pIRHN was correlated with the contents of sialic acid in tumor cells, and there was no prominent evidence for the relatedness of the antitumor effect with the expression of p53 and bcl-2. Conclusion: pIRHN may become a new antitumor biological agent.
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